Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C31H41N6O7.Na |
| Molecular Weight | 632.683 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC([O-])=O)NC(=O)[C@@H](CC3=CNC4=CC=CC=C34)NC1=O)C(C)C
InChI
InChIKey=FLIKEIGEOXCRRG-JKNHBXRPSA-M
InChI=1S/C31H42N6O7.Na/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21;/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39);/q;+1/p-1/t21-,22+,23+,24-,26+;/m0./s1
BQ-123 is a selective endothelin receptor-1 antagonist; it is used as a biochemical tool in the study of endothelin receptor function. BQ-123 was suspected to contribute to the regulation of vascular tone humans. However, a study involving young normotensive subjects did not demonstrate any major role for BQ-123 regulation of vascular tone.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Demonstration of a vasopressor role of endogenous endothelin after inhibition of nitric oxide synthesis in rats]. | 1995 Aug |
|
| ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro. | 1995 May |
|
| Angiotensin II receptor blockade unmasks a depressor response to endothelin antagonists in rats. | 2000 Mar-Apr |
|
| Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries. | 2001 Sep 4 |
|
| Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer. | 2002 Apr |
|
| Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells. | 2002 Mar 1 |
|
| Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons. | 2003 Aug |
|
| Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo. | 2003 Aug |
|
| Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia. | 2003 Jan |
|
| Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes. | 2003 Jul |
|
| Developmental changes in the functional, biochemical and molecular properties of rat bladder endothelin receptors. | 2003 May |
|
| Endothelin ET(A) but not ET(B) receptors mediate contraction of common bile duct. | 2003 May 15 |
|
| Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types. | 2004 Aug |
|
| Obligatory role for endogenous endothelin in mediating the hypertrophic effects of phenylephrine and angiotensin II in neonatal rat ventricular myocytes: evidence for two distinct mechanisms for endothelin regulation. | 2004 Jul |
|
| Ventricular nonmyocytes inhibit doxorubicin-induced myocyte apoptosis: involvement of endogenous endothelin-1 as a paracrine factor. | 2004 May |
|
| Endothelin 1 versus endothelin 3 in the development of the slow force response to myocardial stretch. | 2005 Apr |
|
| Intercellular communication via gap junctions in activated rat hepatic stellate cells. | 2005 Feb |
|
| Endothelin isoforms and the response to myocardial stretch. | 2005 Jun |
|
| Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. | 2005 May |
|
| Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation. | 2005 Nov |
|
| Modulation of the myocardial effects of selective ETB receptor stimulation and its implications for heart failure. | 2005 Sep |
|
| Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid. | 2006 Aug |
|
| Mechanisms of direct peritoneal resuscitation-mediated splanchnic hyperperfusion following hemorrhagic shock. | 2007 Apr |
|
| NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts. | 2007 Sep 1 |
|
| Molecular analysis of cocaine-induced endothelial dysfunction: role of endothelin-1 and nitric oxide. | 2008 Dec |
|
| Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways. | 2009 Apr |
|
| Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. | 2010 Jun |
|
| Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. | 2011 Nov |
|
| Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes. | 2011 Sep 30 |
|
| Selective ET(A) receptor blockade protects against cisplatin-induced acute renal failure in male rats. | 2014 May 5 |
|
| BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. | 2015 Feb 1 |
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DBSALT002128
Created by
admin on Sat Dec 16 11:00:45 GMT 2023 , Edited by admin on Sat Dec 16 11:00:45 GMT 2023
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53229988
Created by
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136655-57-7
Created by
admin on Sat Dec 16 11:00:45 GMT 2023 , Edited by admin on Sat Dec 16 11:00:45 GMT 2023
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05427HSQ1I
Created by
admin on Sat Dec 16 11:00:45 GMT 2023 , Edited by admin on Sat Dec 16 11:00:45 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
