| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H12O3 |
| Molecular Weight | 276.2861 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C)C=CC=C34
InChI
InChIKey=AIGAZQPHXLWMOJ-UHFFFAOYSA-N
InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
Tanshinone I derived from the traditional herbal medicine, Salvia miltiorrhiza Bunge, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. It was discovered, that tanshinone I may serve as an effective drug for the treatment of breast cancer. In addition, it induced apoptosis and pro-survival autophagy via inhibiting Bcl-2 expression on gastric cancer, and the combination of chloroquine and Tanshinone I could inhibit tumor growth more efficiently than monotherapy, which might be considered as an effective strategy for the treatment for gastric cancer. Tanshinone I showed in vivo anti-inflammatory activity via inhibition of type IIA human recombinant sPLA2 (phospholipase A (2)).
Approval Year
PubMed
Patents
Sample Use Guides
It was investigated the effect of tanshinone I on cancer growth, invasion and angiogenesis on human breast cancer cells MDA-MB-231, both in vitro and in vivo. Tanshinone I dose dependently inhibited ICAM-1 and VCAM-1 expressions in human umbilical vein endothelial cells (HUVECs) that were stimulated with TNF-alpha for 6 h. Pretreatment with tanshinone I significantly reduced adhesion of monocyte either U937 or MDA-MB-231 cells to HUVECs.
ACTIVE MOIETY
