AMINAPHTHONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H15NO4
Molecular Weight	309.316
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(O)C2=C(C=CC=C2)C(O)=C1OC(=O)C3=CC=C(N)C=C3

InChI

InChIKey=YLMPBJUYFTWHKJ-UHFFFAOYSA-N

InChI=1S/C18H15NO4/c1-10-15(20)13-4-2-3-5-14(13)16(21)17(10)23-18(22)11-6-8-12(19)9-7-11/h2-9,20-21H,19H2,1H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29059024 | http://www.anvisa.gov.br/datavisa/fila_bula/frmVisualizarBula.asp?pNuTransacao=2698202015&pIdAnexo=2538613 | https://www.ncbi.nlm.nih.gov/pubmed/23761871 | https://www.ncbi.nlm.nih.gov/pubmed/27083548

Aminaphtone, a synthetic molecule derived from 4-aminobenzoic acid, is a drug affecting vessel functioning. Aminaphtone significantly protects endothelium permeability and stabilises endothelial cells organised in capillary-like structures, modulating VE-cadherin expression. In addition aminaphtone modulate expression of several inflammatory and vasoactive factors. Aminaphtone (Capilarema) is used in the treatment of vascular disorders, especially chronic venous disease.

Approval Year

Sample Use Guides

In Vivo Use Guide

2 tablets (75 mg) 2 times daily for 5 days

Route of Administration: Oral

In Vitro Use Guide

ECV-304 endothelial cells were stimulated with IL-1β 100U/ml in the presence or absence of Aminaphtone 6 μg/ml

Name

Type

Language

AMINAPHTHONE

Common Name

English

1,2,4-NAPHTHALENETRIOL, 3-METHYL-, 2-(P-AMINOBENZOATE)

Common Name

English

1,2,4-NAPHTHALENETRIOL, 3-METHYL-, 2-(4-AMINOBENZOATE)

Common Name

English

AMINAPHTONE

Common Name

English

CAPILLAREMA

Brand Name

English

Aminaphtone [WHO-DD]

Common Name

English

AMINAFTONE

Common Name

English

AMINAPHTHONE [MART.]

Common Name

English

(1,4-DIHYDROXY-3-METHYLNAPHTHALEN-2-YL) 4-AMINOBENZOATE

Systematic Name

English

AMINONAPHTHONE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID00163725