MITOCLOMINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H19Cl2NO
Molecular Weight	312.234
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MITOCLOMINE

Structure Search

SMILES

COC1=C(C)C=C(N(CCCl)CCCl)C2=C1C=CC=C2

InChI

InChIKey=CLZXREZAEIUCGG-UHFFFAOYSA-N

InChI=1S/C16H19Cl2NO/c1-12-11-15(19(9-7-17)10-8-18)13-5-3-4-6-14(13)16(12)20-2/h3-6,11H,7-10H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/769961 | https://www.ncbi.nlm.nih.gov/pubmed/716471

Mitoclomine, an alkylating agent was developed to treat cancer. This drug was involved in phase I/II clinical trial to treat patients with chronic lymphocytic leukemia. Information about the further development of a drug is not available.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Investigations into the lymphopaenic and immunosuppressive properties of the antitumour agent, mitoclomine.	1971 Jun	5089346
Disposition of a new alkylating agent [14C]mitoclomine (N,N-bis(2'-chloroethyl)4-amino-2-methyl-1-methoxy-naphthalene).	1978 Oct	716471

Name

Type

Language

MITOCLOMINE

Official Name

English

N,N-BIS(2-CHLOROETHYL)-4-METHOXY-3-METHYL-1-NAPHTHYLAMINE

Systematic Name

English

NSC-114575

Code

English

mitoclomine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C697

Created by admin on Fri Dec 15 16:13:17 GMT 2023 , Edited by admin on Fri Dec 15 16:13:17 GMT 2023

Code System Code Type Description

EVMPD

SUB09002MIG

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ECHA (EC/EINECS)

241-687-9

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INN

2410

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PUBCHEM

28694

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SMS_ID

100000080896

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NCI_THESAURUS

C66164

Created by admin on Fri Dec 15 16:13:17 GMT 2023 , Edited by admin on Fri Dec 15 16:13:17 GMT 2023

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FDA UNII

02DQX562CR

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CAS

17692-54-5

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ChEMBL

CHEMBL2106926

Created by admin on Fri Dec 15 16:13:17 GMT 2023 , Edited by admin on Fri Dec 15 16:13:17 GMT 2023

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EPA CompTox

DTXSID30170220

Created by admin on Fri Dec 15 16:13:17 GMT 2023 , Edited by admin on Fri Dec 15 16:13:17 GMT 2023

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MESH

C012444

Created by admin on Fri Dec 15 16:13:17 GMT 2023 , Edited by admin on Fri Dec 15 16:13:17 GMT 2023

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NSC

114575

Created by admin on Fri Dec 15 16:13:17 GMT 2023 , Edited by admin on Fri Dec 15 16:13:17 GMT 2023

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ACTIVE MOIETY


					02DQX562CR