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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6N4O5
Molecular Weight 226.1463
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NIFURALDEZONE

SMILES

NC(=O)C(=O)NN=CC1=CC=C(O1)[N+]([O-])=O

InChI

InChIKey=AJSKOLZKIUMPPG-YCRREMRBSA-N
InChI=1S/C7H6N4O5/c8-6(12)7(13)10-9-3-4-1-2-5(16-4)11(14)15/h1-3H,(H2,8,12)(H,10,13)/b9-3+

HIDE SMILES / InChI

Description

Nifuraldezone is an antibacterial compound. It completely mimics the radiosensitizing effect of molecular oxygen in hypoxic mammalian cells in vitro at concentrations in tissue culture medium which showed no measurable acute toxicity.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Nifuraldezone has been tested with Chinese hamster cells growing in vitro to determine its toxicity and radiosensitizing effectiveness. The most effective compound tested was nifuraldezone which at 250 μm in complete medium gave the same extent of radiosensitization (ER∼2·85) as oxygen in the air-saturated medium.