NIFURALDEZONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6N4O5
Molecular Weight	226.1463
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C(=O)NN=CC1=CC=C(O1)[N+]([O-])=O

InChI

InChIKey=AJSKOLZKIUMPPG-YCRREMRBSA-N

InChI=1S/C7H6N4O5/c8-6(12)7(13)10-9-3-4-1-2-5(16-4)11(14)15/h1-3H,(H2,8,12)(H,10,13)/b9-3+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4798767

Nifuraldezone is an antibacterial compound. It completely mimics the radiosensitizing effect of molecular oxygen in hypoxic mammalian cells in vitro at concentrations in tissue culture medium which showed no measurable acute toxicity.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Nifuraldezone has been tested with Chinese hamster cells growing in vitro to determine its toxicity and radiosensitizing effectiveness. The most effective compound tested was nifuraldezone which at 250 μm in complete medium gave the same extent of radiosensitization (ER∼2·85) as oxygen in the air-saturated medium.

Name

Type

Language

NIFURALDEZONE

Official Name

English

NSC-3184

Code

English

nifuraldezone [INN]

Common Name

English

ACETIC ACID, AMINOOXO-, ((5-NITRO-2-FURANYL)METHYLENE)HYDRAZIDE

Common Name

English

5-Nitro-2-furaldehyde semioxamazone

Common Name

English

FURAMAZONE [GREEN BOOK]

Common Name

English

NF-84

Code

English

FURAMAZONE

Common Name

English

NIFURALDEZONE [USAN]

Common Name

English

FRAMAZONE

Common Name

English

NIFURALDEZONE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394