Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H8BrN4O3.Na |
| Molecular Weight | 371.121 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].BrC1=CC=C(C=C1)C2=CN=C(O2)\C=N\N3CC(=O)[N-]C3=O
InChI
InChIKey=PHJRJPWBPXLNAJ-FPUQOWELSA-M
InChI=1S/C13H9BrN4O3.Na/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20;/h1-6H,7H2,(H,17,19,20);/q;+1/p-1/b16-6+;
Azumolene is a direct-acting, skeletal muscle relaxant with structural similarities to dantrolene. It is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry (SOCE) coupled to activation of type 1 ryanodine receptor (RyR1) by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected. Azumolene distinguishes between two mechanisms of cellular signaling to SOCE in skeletal muscle, one that is coupled to and one independent from RyR1. Azumolene is equipotent to dantrolene sodium in blocking pharmacologic-induced muscle contractures and that azumolene is efficacious for treatment/prevention of malignant hyperthermia.
Approval Year
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143169
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00N857K16Y
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admin on Sat Dec 16 06:01:46 GMT 2023 , Edited by admin on Sat Dec 16 06:01:46 GMT 2023
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13724090
Created by
admin on Sat Dec 16 06:01:46 GMT 2023 , Edited by admin on Sat Dec 16 06:01:46 GMT 2023
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105336-14-9
Created by
admin on Sat Dec 16 06:01:46 GMT 2023 , Edited by admin on Sat Dec 16 06:01:46 GMT 2023
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ACTIVE MOIETY
SUBSTANCE RECORD
