Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | V |
| Molecular Weight | 50.9415 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[V]
InChI
InChIKey=LEONUFNNVUYDNQ-UHFFFAOYSA-N
InChI=1S/V
DescriptionCurator's Comment: description was created based on several sources, including
http://www.hmdb.ca/metabolites/HMDB02503 | https://www.ncbi.nlm.nih.gov/mesh/68014639 | https://www.ncbi.nlm.nih.gov/pubmed/12050018
Curator's Comment: description was created based on several sources, including
http://www.hmdb.ca/metabolites/HMDB02503 | https://www.ncbi.nlm.nih.gov/mesh/68014639 | https://www.ncbi.nlm.nih.gov/pubmed/12050018
Vanadium (V) is a steel-grey, corrosion-resistant metal. Because of its hardness and its ability to form alloys, vanadium (i.e., ferrovanadium) is a common component of hard steel alloys used in machines and tools. Although most foods contain low concentrations of vanadium (< 1 ng/g), food is the major source of exposure to vanadium for the general population. Vanadium is probably an essential trace element, but a vanadium-deficiency disease has not been identified in humans. At pharmacological doses, vanadium compounds display relevant biological actions such as mimicking insulin and growth factors as well as having osteogenic activity. Some vanadium compounds also show antitumoral properties.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Minerals in the municipal water and atherosclerotic heart death. | 1971 Apr |
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| Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital. | 1995 Jun |
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| Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent. | 1997 Oct |
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| Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. | 1998 Jun |
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| Vanadium: a review of its potential role in the fight against diabetes. | 1999 Jun |
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| Inhibition of HIV-1 infection by zinc group metal compounds. | 1999 Sep |
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| Lung mucin production is stimulated by the air pollutant residual oil fly ash. | 2000 Jan 15 |
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| Effect of peroxovanadate compound on phenylalanine hydroxylase gene expression. | 2000 Jun |
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| Trace elements in regulation of NF-kappaB activity. | 2000 Oct |
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| Differential ability of transition metals to induce pulmonary inflammation. | 2001 Nov 15 |
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| Vanadium--an element of atypical biological significance. | 2004 Apr 21 |
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| Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells. | 2004 Jan |
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| Metal particulate matter components affect gene expression and beat frequency of neonatal rat ventricular myocytes. | 2004 May |
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| Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor. | 2005 Aug |
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| [Regulatory effects of micronutrient complex on the expression of Th1 and Th2 cytokines in diabetic C57BL mice]. | 2005 Jan |
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| Vanadium induces apoptosis and modulates the expressions of metallothionein, Ki-67 nuclear antigen, and p53 during 2-acetylaminofluorene-induced rat liver preneoplasia. | 2005 Mar 1 |
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| Protective role of vanadium on the early process of rat mammary carcinogenesis by influencing expression of metallothionein, GGT-positive foci and DNA fragmentation. | 2005 Nov-Dec |
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| Divalent metal transporter-1 decreases metal-related injury in the lung. | 2005 Sep |
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| Oral vanadium enhances the catabolic effects of central leptin in young adult rats. | 2006 Jan |
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| Vanadium and insulin increase adiponectin production in 3T3-L1 adipocytes. | 2006 Jul |
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| Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. | 2006 Jun 15 |
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| Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and -2 and iNOS expression during ongoing alteration in iron homeostasis. | 2006 May |
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| Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model. | 2006 May 8 |
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| Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats. | 2006 Oct |
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| Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression. | 2006 Oct |
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| Upregulation of LITAF mRNA expression upon exposure to TiAlV and polyethylene wear particles in THP-1 macrophages. | 2007 Apr |
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| Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process. | 2007 Jan |
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| Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats. | 2007 May 1 |
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| Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction. | 2008 Feb 29 |
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| Source apportionment of particulate matter in the U.S. and associations with lung inflammatory markers. | 2008 May |
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| Endothelial effects of emission source particles: acute toxic response gene expression profiles. | 2009 Feb |
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| Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice. | 2009 Mar |
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| Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells. | 2009 May 1 |
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| Transcriptional and posttranscriptional regulation of CYP1A1 by vanadium in human hepatoma HepG2 cells. | 2010 Oct |
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| Nicotine attenuates spatial learning deficits induced by sodium metavanadate. | 2012 Jan |
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| Modulation of cytochrome P450 1 (Cyp1) by vanadium in hepatic tissue and isolated hepatocyte of C57BL/6 mice. | 2013 Aug |
Patents
Sample Use Guides
Tolerable upper intake level for adults is 1.8 mg/day.
Route of Administration:
Oral
Vanadate (V) ions competitively inhibit calf thymus terminal deoxynucleotidyl transferase with Ki = 2.5 microM. A binding of vanadium to the enzyme with no change of the amount of the Zn constituent of the protein was found at concentrations of vanadate causing inhibition. The catalytic activity of mammalian DNA polymerase alpha was also inhibited by vanadate ions at an I50 of 60 microM, while the bacterial (E. coli) DNA polymerase I was affected to the same extent only when the concentration of vanadate was raised to about 0.5 mM. In contrast to the inhibitory effects caused by vanadium on the nucleotidyl transferases, concentrations of pentavalent vanadium ions of the order of 10 microM increase 2.4-fold the hydrolytic activity of deoxyribonuclease I from bovine pancreas.
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132 (Number of products:1869)
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DB13971
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SUB37143
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ACTIVE MOIETY
