U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 7071 - 7080 of 9777 results

mixture
Status:
Investigational
Source:
USAN:PAFLUFOCON D-HEM-IBERFILCON A [USAN]
Source URL:

Class:
MIXTURE

mixture
Status:
Investigational
Source:
USAN:PETRAFOCON A-HEM-LARAFILCON A [USAN]
Source URL:

Class:
MIXTURE

mixture
Status:
Investigational
Source:
USAN:PLECTRANTHUS AMBOINICUS EXTRACT [USAN]
Source URL:

Class:
MIXTURE

mixture
Status:
Investigational
Source:
NCT01941966: Phase 2 Interventional Completed Anal Canal Cancer.
(2010)
Source URL:

Class:
MIXTURE

mixture
Status:
Investigational
Source:
INN:metazocine
Source URL:

Class:
MIXTURE

Metazocine is a synthetic opioid analgesic with reinforcing properties and PCP-like activity. Metazocine is a Schedule II controlled substance. Metazocine acts as a ligand at opioid, sigma and NMDA receptors. Metazocine enantiomers exert different pharmacological activity.
mixture
Status:
Investigational
Source:
NCT02579876: Phase 2 Interventional Completed Eosinophilic Esophagitis
(2015)
Source URL:

Class:
MIXTURE

mixture
Status:
Investigational
Source:
INN:orientiparcin
Source URL:

Class:
MIXTURE

Orientiparcin is a mixture of two glycopeptide antibiotic complexes: orienticins A and D. Orientiparcin showed a broad spectrum of antibacterial activity. However, information about the current use of this drug is not available.
mixture
Status:
Investigational
Source:
NCT04487860: Phase 2 Interventional Completed Non-segmental Vitiligo
(2021)
Source URL:

Class:
MIXTURE

mixture
Status:
Investigational
Source:
INN:clofenvinfos
Source URL:

Class:
MIXTURE

Clorfenvinfos (chlorfenvinphos) is an organophosphate insecticide, which is used to control insect pests on livestock, and to control household pests such as flies, fleas, and mites. Clorfenvinfos was sold under trade names including Birlane®, Dermaton®, Sapercon®, Steladone®, and Supona®. In 1991 all products containing clorfenvinfos were banned in the USA. Toxicity of clorfenvinfos is due to inhibition of acetylcholinesterase. Inhibition of cholinesterase activity results in the accumulation of acetylcholine at muscarinic and nicotinic receptors. This leads to continuous or excessive stimulation of cholinergic fibers in the post-ganglionic parasympathetic nerve endings, neuromuscular junctions of the skeletal muscles, resulting in hyperpolarization of nerve or muscle fibers and receptor desensitization until hydrolysis of the phosphorylated cholinesterase occurs. In some cases, a dealkylation and stabilization of the phosphorylated enzyme (“aging”) occur such that hydrolysis can no longer take place and the enzyme is irreversibly inhibited. In such cases, the return of acetylcholinesterase activity parallels the time required to resynthesize this enzyme.

Showing 7071 - 7080 of 9777 results