U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 6951 - 6960 of 9777 results

Status:
Investigational
Source:
INN:brocresine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Brocresine, an aromatic L-amino acid decarboxylase inhibitor with both a peripheral and central action was shown to potentiate the therapeutic effect of levodopa in Parkinson's disease.
Status:
Investigational
Source:
INN:sulfapyrazole
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Sulfazamet is a sulfanilamide derivative that exhibits antibacterial activity against Streptococci sepsis
Status:
Investigational
Source:
INN:norucholic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
NCT01691521: Not Applicable Human clinical trial Completed Pulmonary Eosinophilia
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:doretinel
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Doretinel is a member of a class of compounds known collectively as retinoids. As a topical gel, it was being studied for its potential use as a dermatological product.
Status:
Investigational
Source:
INN:sulofenur [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Sulofenur is an orally active diarylsulfonylurea derivative patented by American pharmaceutical company Eli Lilly and Co. as an antitumor agent. In preclinical studies, Sulofenur exhibits significant activity against advanced colon adenocarcinoma xenografts intrinsically resistant to virtually all standard chemotherapeutic agents and also had very significant activity against several pediatric tumors grown as xenografts. Clinically, Sulofenur was disappointing, and although some responses were reported in phase I trials this was not confirmed for ovarian cancer in the phase II setting. Toxicity in man was due mainly to methemoglobinemia and anemia, which limited the concentrations of drug that could be achieved to levels well below those shown to elicit a therapeutic response in the xenograft models.
Status:
Investigational
Source:
J Surg Oncol. 1979;11(4):313-23.: Phase 3 Human clinical trial Completed Soft Tissue Neoplasms
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:tiacrilast
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Tiacrilast (also known as Ro 22-3747) is a quinazolinyl-propenoic acid derivative patented by Hoffmann-La Roche, Inc. as an antihypertensive useful for anaphylaxis management. Tiacrilast acts as a potent mast cell degranulation inhibitor in vitro and inhibits of antigen-induced histamine release from passively sensitized rat peritoneal cells in vitro. In preclinical models, Tiacrilast shows marked activity in rat passive cutaneous anaphylaxis assay, rat anaphylactic bronchospasm assay. In vitro studies have confirmed that the mechanism of action of Tiacrilast in the in vivo models is through allergic mediator release inhibition. Clinical evaluations of Tiacrilast in patients with ragweed sensitive allergic asthma, Tiacrilast demonstrates significant inhibitory activity relative to placebo in reducing acute airway responses to inhaled pollen extracts
Status:
Investigational
Source:
INN:thyropropic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Thyropropic Acid (also known as Triopron) is a hydrocinnamic acid derivative and naturally occurring thyroid analog with antigoitrogenic and anticholesteremic activity. Thyropropic Acid acts as potent antagonist of thyroid hormone receptors and may be useful in the therapy of resistance to thyroid hormone and corticosteroid-induced skin atrophy. In preclinical models, Thyropropic Acid reduced serum cholesterol 27% and liver incorporation of acetate into cholesterol 37% but did not affect liver cholesterol levels.
Status:
Investigational
Source:
INN:tiamiprine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Thiamiprine is a cytotoxic purine derivative patented by Wellcome Foundation Ltd. as an immunosuppressive and antineoplastic agent. In preclinical models, Thiamiprine is active against a variety of transplantable rodent tumors and in the rat adjuvant arthritis model.

Showing 6951 - 6960 of 9777 results