U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 6941 - 6950 of 9777 results

Status:
Investigational
Source:
INN:proquinolate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Proquinolate is a quinoline derivative patented by Norwich Pharmacal Co. as an antiparasitic agent used to control coccidiosis in the chicken industry.
Status:
Investigational
Source:
INN:doxenitoin [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Doxenitoin is a phenytoin-like structure, the only difference being reduction of the carbonyl at the 2-position to a methylene group. This drug has significant anticonvulsant potency. It was developed as an antiepileptic agent.
Status:
Investigational
Source:
INN:iosefamic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Iosefamic Acid is triiodoisophthalamic acid derivative patented by Mallinckrodt Chemical Works as x-ray contrast agent for imaging in the biliary and urinary systems and in vasography.
Status:
Investigational
Source:
USAN:Amotriphene
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Amotriphene (Myordil, WIN 5494) is a coronary dilator and cardiac antiarrhythmic properties. It has potential value in the treatment of angina-like conditions and the milder cardiac arrhythmias. Amotriphene binds to α‐adrenergic receptors.
Status:
Investigational
Source:
USAN:PHENBUTAZONE SODIUM GLYCERATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

There is no information about biological and/or pharmacological application of phenbutazone sodium glycerate.
Status:
Investigational
Source:
INN:difluanazine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Difluanine is the central nervous system stimulant.
Status:
Investigational
Source:
INN:dimpylate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Dimpylate (diazinon) is a nonsystemic organophosphate insecticide, an inhibitor of the enzyme acetylcholinesterase (AChE), which hydrolyzes the neurotransmitter acetylcholine (ACh) in cholinergic synapses and neuromuscular junctions. This results in abnormal accumulation of ACh in the nervous system. Dimpylate was first registered for use in the USA in 1956. It was developed as an insecticide, acaricide, and nematicide for use on a variety of pests for control of soil insects and pests of fruit, vegetables, and forage and field crops. It had been used extensively in home and garden applications, in formulations designed to prevent such pests as crickets or cockroaches from infesting homes or offices, and in pet collars. Due to the emerging health and ecological risks posed by diazinon, manufacturers agreed to phase out and cancel all residential products. Manufacturing of indoor use products containing dimpylatewas discontinued in 2001; manufacture of non-agricultural outdoor use products containing dimpylate was discontinued in 2003.
Status:
Investigational
Source:
INN:fenamole [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:


Fenamole is a muscle relaxant. It is effectively inhibits muscle spasms at good levels for a four hours and at significant levels for six hours. Clinical benefits were derived in patients with spasticity-spasm for periods up to 24 hours after a single oral dose. Fenamole is relatively free of adverse side effects particularly in the central nervous system. It is a potent copper chelator. It was once investigated as a potential antirheumatic agent in man.
Status:
Investigational
Source:
INN:tetroquinone [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Tetroquinone (Tetrahydroxy-1,4-benzoquinone, tetrahydroxy-p-benzoquinone, tetrahydroxybenzoquinone) is cyclohexadiene derivative with four hydroxyl groups and two ketone groups in opposite (para) positions, with potent prooxidant activity. The exposure of exponentially growing cultures to Tetroquinone, in the presence of Ca2+, caused a dose-dependent inhibition of cell growth and DNA synthesis. The chemical reactivity of Tetroquinone is strongly similar to those of physiological polyphenols, such as catechols and catecholamines. Despite their physiological and pharmacological roles, these compounds may, in addition, present toxicological properties due to their ability to autoxidize generating ROS and quinones Similar to catechols, the OH-substituents confer to Tetroquinone the ability to autoxidize readily in neutral aqueous solutions generating intermediate superoxide anion radicals, semiquinone radicals, and the corresponding quinone. The compound can be synthesized from glyoxal or from myo-inositol (phytic acid), a natural compound widely present in plants.
Status:
Investigational
Source:
INN:hydroxystenozole
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Hydroxystenozole is an orally active anabolic-androgenic steroid (AAS) that was described in the literature in 1967 but was never marketed.

Showing 6941 - 6950 of 9777 results