U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 6221 - 6230 of 12702 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

BENFURODIL, a 5-benzofuran derivative, is an arterioleptic drug used in the treatment of different arteriopathies.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Hexapropymate, a hypnotic/sedative drug that was available without prescription in Belgium under the trade name Merinax for the treatment of insomnia. Poisoning with hexapropymate was a serious condition that required symptomatic treatment in the intensive care unit. As a result, the drug was substituted by newer agents with improved safety profiles.
Status:
Possibly Marketed Outside US
Source:
CFR:21 CFR 250.102
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Octyl nitrite is a clear light-colored liquid. May be toxic by ingestion. May severely irritate skin upon contact. Octyl nitrite (2-ethyl-n-hexyl-1-nitrite) is a liquid nitrite of one of the higher alcohols which, because of its volatility, can be administered by inhalation. Krantz, Carr, and Forman, who first prepared this substance, state that in laboratory animals it produces a fall in systemic blood pressure and an increase in the coronary blood flow; it dilates isolated coronary artery rings, and, in normal men, the inhalation of large doses (0.2 c.c. for one minute) produces a moderate fall in blood pressure, together with a moderate increase in heart rate. Octyl nitrite proved to be effective in treatment of Angina pectoris. This was shown objectively, not only by an increased ability to work after inhalation of the drug, but also by a definite decrease in the duration of the attacks in some cases. Furthermore, this drug, like others which are effective in angina pectoris, prevents the development of the electrocardiographic changes which ordinarily occur on exertion in patients with angina. Octyl nitrite is apparently similar in its action to nitroglycerin and amyl nitrite, and it has all of their advantages and disadvantages. It differs from nitroglycerin primarily in that, being volatile, it can be administered by inhalation. The Food and Drug Administration finds that "coronary vasodilators" (Octyl nitrite) are extensively regarded by physicians as safe and useful as employed under medical supervision for the management of angina pectoris in some patients. The Food and Drug Administration also finds that there is neither substantial evidence of effectiveness nor a general recognition by qualified experts that such drugs are effective for any of the other purposes for which some such drugs are promoted to the medical profession in labeling and advertising. In particular, neither clinical investigations nor clinical experience justify any representations that such drugs are effective in the management of hypertension; in the management of coronary insufficiency or coronary artery disease, except for their anginal manifestations; or in the management of the post coronary state, except angina pectoris present after coronary occlusion and myocardial infarction.
Status:
Possibly Marketed Outside US
Source:
Sulfabrom by English, J.P. et al.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfabromomethazine is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis and various bacterial infections. Single oral doses of the drug have been used to treat calf diphteria and pneumonia, metritis, foot root and septic mastitis in cattle with repeated dose 48 hors later sometimes required. Use of sulfabromomethazine during the last 3 months of pregnancy should be avoided. The compound is now rarely used.
Status:
Possibly Marketed Outside US
Source:
Fenthion by Brady, U.E.|Arthur, B.W.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Fenthion (trade names include Baytex™, Baycid™, and Tiguvon™, used on livestock) was first registered domestically in 1965 by the Mobay Corp., a U.S. subsidiary of Bayer AG of West Germany. Fenthion is a contact and stomach insecticide used against many sucking, biting pests, especially fruit flies, stem borers, mosquitoes, and Eurygaster cereal bugs. In mosquitoes, it is toxic to both the adult and immature forms (larvae). Once used extensively in the U.S. for controlling intestinal worms, fenthion no longer has FDA approval due to an excess number of poisoning deaths. Like most other organophosphates, its mode of action is via cholinesterase inhibition. It was used mostly for the control of grubs and lice in beef and nonlactating cattle.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Cythioate is an organothiophosphate chemical used as an insecticide and anthelmintic. Cythioate is a cholinesterase inhibitor. Marketed under the trade names Cyflee and Proban, Cythioate is indicated for the control of ticks, fleas, and demodectic mange in dogs, and fleas in cats.
Status:
Possibly Marketed Outside US
Source:
UK NHS:Moxisylyte hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction, also was studied, that this drug may be useful to treat ocular disorders such as diabetic retinopathy. It is an alpha1-adrenergic antagonist. Was developed for self-injection therapy in France and marketed in several European countries as Icavex. In the spring 2005 the manufacturer of Icavex decided to withdraw this drug from Europe market, presumable due to its low market shares.
Status:
Possibly Marketed Outside US
Source:
Canada:ARSANILIC ACID
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Arsanilic acid, also known as aminophenyl arsenic acid or aminophenyl arsonic acid, is an organoarsenic compound first reported in 1863 by Antoine Béchamp. Arsanilic acid is a crystalline powder introduced medically in the late 19th century as Atoxyl, its sodium salt was used by injection in the early 20th century as the first organic arsenical drug, but it was soon found prohibitively toxic for human use. Arsanilic acid saw long use as a veterinary feed additive promoting growth and to prevent or treat dysentery in poultry and swine. In 2013, its approval by US government as an animal drug was voluntarily withdrawn by its sponsors. Still sometimes used in laboratories, Arsanilic acid's legacy is principally through its influence on Paul Ehrlich in launching the chemotherapeutic approach to treating infectious diseases of humans.
Status:
Possibly Marketed Outside US
Source:
Japan:Aniracetam
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Aniracetam is a nootropic drug. It behaves as a positive modulator of AMPA-sensitive glutamate receptors. Aniracetam is clinically used in patients with mild to moderate senile dementia of the Alzheimer type. In Japan, the drug was prescribed for eight years to treat emotional disturbances, such as depressed mood and anxiety/agitation, but not memory impairment following cerebral infarction. Aniracetam (Draganon®) has been withdrawn from the Japanese market because of the unexpected failure in the latest placebo-controlled double-blind study. Animal studies demonstrated that aniracetam has clinical potential in personality disorders, anxiety, depression, posttraumatic stress disorder, attention-deficit/hyperactivity disorder, autism, negative symptoms of schizophrenia, and sleep disorders.

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Buramate is a safe drug, which shows definite anticonvulsant activity in cases of mixed Patit Mal and Grand Mal. Together with ACTH, it was used as an anti-epileptic drug in the therapy of infantile myoclonic seizures and petitmal epilepsy.

Showing 6221 - 6230 of 12702 results