U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 6181 - 6190 of 12702 results

Status:
Possibly Marketed Outside US
Source:
Apo-benzydamine Oral Rinse by Apotex Corporation [Canada]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Benzydamine (benzydamine hydrochloride, PHARIXIA®) is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is indicated for the relief of pain in acute sore throat and for the symptomatic relief of oro-pharyngeal mucositis caused by radiation therapy.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Dimestrol (Diethylstilbestrol, DES) is a synthetic nonsteroidal estrogen. It was prescribed to pregnant women between 1940 and 1971 to prevent miscarriage, premature labor, and related complications of pregnancy. The use of DES declined after studies in the 1950s showed that it was not effective in preventing these problems. In 1971, the FDA issued a warning that risk of clear cell adenocarcinoma of the vagina and cervix was elevated in young women whose mothers used DES during pregnancy.
Status:
Possibly Marketed Outside US
Source:
Japan:Tolciclate
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)



Tolciclate [O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl)-m,N-dimethylthiocarbanilate] is an antimycotic agent with specific activity on dermatophytes. In vitro it is as active as tolnaftate, but shows greater liposolubility, which might be important for in vivo activity. When applied topically for 10 days to guinea pigs infected acutely with Trichophyton mentagrophytes (synonymous with T. asteroides), it is about three times more active than tolnaftate. Inhibition by tolciclate of sterol synthesis through blocking the step of squalene epoxidation in a fungal sterol biosynthetic pathway may be primarily involved in the antifungal action of the drug.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Methylthiouracil is an orally active thyroid enzyme activity inhibitor. Methylthiouracil was introduced in the mid-1940s for the treatment of hyperthyroidism. Methylthiouracil is no longer in clinical use in most countries, although it may be used to a limited degree in some eastern European countries. Methylthiouracil possess anti-inflammatory effects in vitro and in vivo and was found effective in a murine model of sepsis.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

AZOLIMINE, an imidazolidinone, is a diuretic drug. It can antagonize the effects of mineralocorticoids on electrolyte excretion in the kidneys.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:

Rosoxacin, a quinolone derivative, is an antibiotic, which is used for the treatment of uncomplicated acute gonococcal urethritis. Administration of rosoxacin is an effective regimen for the therapy of chancroid and is a reasonable alternative to other short-course regimens. The drug binds to and inhibits two enzymes topoisomerase II (DNA gyrase), which is required for bacterial DNA replication, transcription, repair, and recombination.
Status:
Possibly Marketed Outside US
Source:
MICOFUR by Eaton Laboratories
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Nifuroxime is anti-infective agent used in protozoal & fungal infections. The combination of furazolidone and nifuroxime in vaginal suppositories and vaginal insufflation powder was found to be an effective trichomonacidal compound. Nifuroxime was marketed under the brand name Nifurat, Nifurat consists of Attapulgite and Nifuroxime. Nifurat is an oral, nonabsorbed medication that is used in the management of diarrhea. It works by adsorbing (binding) large numbers of bacteria and toxins and reducing the loss of water. Nifurat reduces the number of bowel movements, improves the consistency of loose or watery stools, and relieves the gastrointestinal cramping that often is associated with diarrhea. Used for: Nifurat is used for the short-term treatment of diarrhea. Nifuroxime is proposed as a radiosensitizing agent with solid tumors.
Status:
Possibly Marketed Outside US
Source:
Japan:Oxeladin Tannate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Oxeladin citrate is a cough suppressant, is a highly potent and effective drug used to treat all types of cough of various etiologies. Withdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity. Oxeladine is a component of antitussive drug, Altussan, approved in Philippines.
Status:
Possibly Marketed Outside US
Source:
Japan:Pyrithioxine Hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Pyritinol is a semi natural analogue of water soluble vitamin B6. Pyritinol was synthetized way back in 1961 by Merck Laboratories. After years of research, it entered the market in the 1970s, where it was used for clinical applications – including treating stroke patients and those with Alzheimer’s. Since the 1990s, it has been sold as a nootropic dietary supplement in the United States and many other parts of the world. Pyritinol, unlike many other nootropics, has been approved for use as a medical treatment in countries around the world. Doctors in many European countries use Pyritinol to treat patients with chronic degenerative brain disorders – like dementia. Countries where Pyritinol is an approved treatment include Austria, Germany, France, Greece, Italy, and Portugal. France has approved the use of Pyritinol – but only as a treatment for rheumatoid arthritis. Pyritinol is not currently licensed for use in the United Kingdom, but in most other countries, it’s available online or through drug stores as an over the counter substance. Pyritinol is marketed under the brand names Encephabol, Encefabol and Cerbon 6. One of the known mechanisms of action of Pyritinol involves increasing choline uptake into your neurons and thereby increasing acetylcholine levels. Pyritinol is also a great effective precursor to dopamine, which is one of the neurotransmitter mood-boosters in the brain. Pyritinol has better conversion into the neurochemical. This drug increases dopamine, which can keep the brain from anxiety because a lower dopamine level is connected to mood disorders and depression.
Status:
Possibly Marketed Outside US
Source:
Japan:Gallopamil Hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)



Gallopamil is a L-type calcium channel blocker designed for the treatment of coronary heart diseases: angina pectoris, prinzmetal angina and hypertonia.

Showing 6181 - 6190 of 12702 results