U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 34131 - 34140 of 34955 results

Status:
Possibly Marketed Outside US
First approved in 2015

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Skeletal imaging, radionuclide—Technetium Tc 99m oxidronate is indicated as a skeletal imaging agent in adults and children to delineate areas of abnormal osteogenesis, such as those that occur with metastatic bone disease, Paget's disease, arthritic disease, osteomyelitis, and fractures. Technetium Tc 99m oxidronate injection is a radiopharmaceutical. Exact mechanism is not known. It is generally accepted that technetium Tc 99m oxidronate localizes on the surface of hydroxyapatite crystals by a process termed chemisorption, with blood flow and/or blood concentration being most important in the delivery of the agent to sites of uptake. Visualization of osseous lesions is possible since skeletal uptake of technetium Tc 99m oxidronate is altered in areas of abnormal osteogenesis. Rapidly distributed in and cleared from blood after intravenous administration, with about half the dose normally accumulating in the skeleton within 3 to 4 hours after injection. May also locate within infarcted myocardial cells or other regions of soft tissue necrosis or calcification. Minimal uptake by soft-tissue organs, except calcified cartilage, blood vessels, and kidneys. TechneScan HDP exhibits its greatest affinity for areas of altered osteogenesis and actively metabolizing bone. Some hypersensitivity reactions, as well as nausea and vomiting, have been infrequently associated with Technetium Tc 99m Oxidronate.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

Desmeninol is a methionine hydroxyl analog. It is used as a feed additive for livestock, especially poultry to provide an essential amino acid necessary for the nutritional well being of farm raised animals. Desmeninol (ALIMET) has 88% methionine activity and is 100 percent absorbed by the animal. The benefits of ALIMET go beyond it being a methionine source, including: Antioxidant effect in the feed; Maintained performance during heat stress; Energy savings in the feed mill; Increased feed intake.
Status:
Possibly Marketed Outside US
Source:
RIVANOL by Roser|Jensch
Source URL:
First approved in 2015

Class (Stereo):
CHEMICAL (RACEMIC)


Ethacridine (Rivanol) is an acridine derivative indicated for the treatment of bacterial infections. In many countries the drug was in clinical practice for the second trimester termination of pregnancy.
Status:
Possibly Marketed Outside US
First approved in 2014

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Glucuronic acid is a sugar acid that was first identified in urine. It is an intermediate metabolite of the uronic acid pathway. Moreover, glucuronic acid is involved in detoxification of certain drugs and toxins by conjugating with them and forming glucuronides. Glucuronic acid has been found to cause an increase in TLR4-dependent reporter protein expression in a cell line transfected with TLR4 and associated co-signaling molecules, and can cause TLR4-dependent pain in humans.
Palmitoleic acid, commonly known as omega-7, is a rare monounsatured fatty acid, which was generally reported to benefit the skin in promoting epithelialisation, and certain gynaecological problems (vaginal mycoses). Until now, sea buckthorn (Hippophae rhamnoides), a shrub widely found in Europe and Asia, and macadamia nuts have been the principal sources. Palmitoleic acid (PMA) has anti-inflammatory and antidiabetic activities. Palmitoleic acid is a gap junction uncoupler.

Showing 34131 - 34140 of 34955 results